Siponimod
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
ambenonium
Carbamate cholinesterase inhibitor · Anticholinesterase; Treatment for Myasthenia Gravis
Carbamate cholinesterase inhibitorAnticholinesterase; Treatment for Myasthenia Gravis
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
1 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactions
- SiponimodSevereDatabaseDDInter
Mechanism
Ambenonium, a carbamoyl ester linked drug, inhibits acetylcholinesterase (AChE) by serving as an alternate substrate that is hydrolyzed much more slowly than acetylcholine. Its reaction with the active center serine progressively generates a carbamoylated enzyme, leading to prolonged inhibition of AChE-mediated acetylcholine hydrolysis.
Indications
myasthenia gravis
Drug interactions
11 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Ask House about ambenonium
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Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team