Drug reference

Amifampridine

Antiarrhythmic · Treatment for Lambert-Eaton myasthenic syndrome

AntiarrhythmicTreatment for Lambert-Eaton myasthenic syndrome

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

4 major

SEVERE in our sources

PREGNANCY

l BREAST FEEDING

FDA category + note

Top interactions

BupropionSevereDatabaseDDInter
IohexolSevereDatabaseDDInter
IopamidolSevereDatabaseDDInter
TramadolSevereDatabaseDDInter

Mechanism

Amifampridine blocks nerve terminal potassium channels. This action prolongs the action potential duration at the nerve terminal, leading to increased calcium influx. The increased intracellular calcium then enhances transmitter (acetylcholine) release.

Indications

Symptomatic treatment of Lambert-Eaton myasthenic syndrome (LEMS)

Dosing

Adult: after 2–6 months), the dose of prednisolone should be reduced slowly to the minimum effective dose. In generalised myasthenia gravis azathioprine is usually started at the same time as the corticosteroid and it allows a lower maintenance dose of the corticosteroid to be used. Ciclosporin p. 883, methotrexate p. 963, or mycophenolate mofetil p.…