Moclobemide
Contraindicated
Textbook
Increased risk of serotonin syndrome and potentiated sympathomimetic effects.
Should not be used concurrently with MAOIs or within 14 days of stopping MAOIs.
Source: G&G 14e
Drug reference
Amoxapine
TCA · Antidepressant
Also known as ASENDIN
TCAAntidepressant
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 12 →
- MoclobemideContraindicatedTextbookG&G 14e
- AdrenalineSevereTextbookKDT 7e · p365
- ArtemisininsSevereTextbookKDT 7e · p816-835
- Meglumine AntimoniateSevereTextbookHarrison 22e · p1740
Mechanism
Amoxapine primarily inhibits the reuptake of norepinephrine and to a lesser extent, serotonin, thereby increasing their concentrations in the synaptic cleft. Additionally, it acts as an antagonist at 5HT2A and 5HT2C serotonin receptors.
Indications
Depressionpsychotic depression (with first-generation antipsychotics)pain conditions
Dosing
- Adult
- 200–300 mg/day orally
Pharmacokinetics
Half-life
8 hours (parent), 30 hours (active metabolite)
Metabolism
hepatic
Side effects
Common
Anticholinergic effectsSedationHypotensioncognitive dullingblurred visiondry mouthtachycardiaconstipationdifficulty urinatingorthostatic hypotensionweight gain
Serious
- Seizures
- quinidine-like effects on cardiac conduction (life threatening in overdose)
- lowered seizure threshold
- extrapyramidal side effects (e.g., tardive dyskinesia)
- serotonin syndrome (with MAOIs)
Drug interactions
Adrenaline
Severe
Textbook
Potentiation of adrenaline's effects.
Vasoconstrictor (adrenaline) containing LA should be avoided in patients receiving tricyclic antidepressants.
Source: KDT 7e · p365
Artemisinins
Severe
Textbook
Increased risk of cardiac conduction defects.
Source: KDT 7e · p816-835
Meglumine Antimoniate
Severe
Textbook
Increased cardiotoxicity (e.g., QT prolongation).
Source: Harrison 22e · p1740
Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amisulpride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Anagrelide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Arbutamine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Arsenic Trioxide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bedaquiline
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bepridil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bupropion
Severe
Database
May increase plasma exposures of TCAs.
The possibility of drug interactions should be kept in mind until the safety of the combination is firmly established.
Source: DDInter
Related guidelines
Other TCA drugs
Ask House about Amoxapine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Katzung·Verified: 2026-05-10 · House clinical team