Acetazolamide
Moderate
Database
Urinary alkalinisation → reduced excretion/raised levels
Monitor for toxicity
Source: Kimi deep-research + Cla
Drug reference
amphetamines
Dopamine reuptake inhibitor · Stimulant
Dopamine reuptake inhibitorStimulant
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Selectively block dopamine reuptake in brain neurons by dopamine transporter (DAT).
Side effects
Common
addictionstrong reinforcementpsychological dependence (leading to continuous or occasional use)
Drug interactions
Sodium Bicarbonate
Moderate
Database
Increased plasma concentrations and prolonged duration of action of amphetamines, potentially leading to enhanced stimulant effects and toxicity.
Monitor for increased amphetamine effects. Consider dose reduction of amphetamines if co-administration is necessary. Avoid concurrent use if possible, especially in patients prone to cardiac or CNS side effects.
Related guidelines
Ask House about amphetamines
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team