Drug reference

Antithymocyte globulin (rabbit)

Immunosuppressant

Also known as Thymoglobulin, ATG, Antithymocyte immunoglobulin (rabbit)

Immunosuppressant

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

Manufacturer advises use only if potential benefit outweighs risk—no information available.

FDA category + note

Mechanism

Antithymocyte globulin (rabbit) is a polyclonal antibody purified from rabbit immunized with human thymic lymphocytes. It contains antibodies against many CD antigens as well as HLA antigens. It works by binding to T lymphocytes and depleting them, thereby providing a potent immunosuppressive effect.

Indications

Prophylaxis of organ rejection in renal allograft recipientsTreatment of corticosteroid-resistant allograft rejection in renal transplantation

Dosing

Adult: For prophylaxis of organ rejection in renal allograft recipients: 1–2.5 mg/kg daily for 3–5 days, to be given over at least 6 hours by intravenous infusion.…

Contraindications

Infection

Side effects

Common

ChillsDiarrhoeaDysphagiaDyspnoeaFeverHypotensionInfectionLymphopeniaMyalgiaNauseaNeoplasm malignantNeoplasmsNeutropeniaReactivation of infectionSecondary malignancySepsisSkin reactionsThrombocytopeniaVomiting

Serious