Abciximab
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
argatroban
Direct thrombin inhibitor · Anticoagulant
Direct thrombin inhibitorAnticoagulant
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AbciximabSevereDatabaseDDInter
- AcalabrutinibSevereDatabaseDDInter
- AlteplaseSevereDatabaseDDInter
- AnagrelideSevereDatabaseDDInter
Mechanism
Synthetic compound based on the structure of l-arginine, binds reversibly to the active site of thrombin.
Indications
Prophylaxis or treatment of patients with, or at risk of developing, heparin-induced thrombocytopeniaheparin-induced thrombocytopenia (but not for other thrombocytopenias)Short-term indications in patients with heparin induced thrombocytopeniaVTE in the setting of suspected or proven heparin-induced thrombocytopenia
Dosing
- Hepatic adjustment
- Dose reduction is required for patients with hepatic insufficiency.
Pharmacokinetics
Half-life
40 to 50 minutes
Metabolism
Metabolized in the liver
Excretion
Excreted in the bile
Drug interactions
Acalabrutinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alteplase
Severe
Database
Clinical effect not specified
Source: DDInter
Anagrelide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Anisindione
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Anistreplase
Severe
Database
Clinical effect not specified
Source: DDInter
Apixaban
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Ardeparin
Severe
Database
Clinical effect not specified
Source: DDInter
Avapritinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Betrixaban
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bivalirudin
Severe
Database
Clinical effect not specified
Source: DDInter
Cabozantinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
GI bleeding on antiplatelet or anticoagulant therapy
CSI · Cardiology · 2020
Venous thromboembolism prophylaxis
ASH · Haematology · 2018
Anticoagulant management for dental procedures
ADA_DENTAL · Dentistry · 2015
Heart failure in diabetes
RSSDI · Cardiology · 2023
Infective endocarditis prevention
NICE · Cardiology / Dentistry · 2008
Ask House about argatroban
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Harrison 22e·Verified: 2026-05-10 · House clinical team