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avapritinib

KIT and PDGFRA mutant kinases inhibitor · Antineoplastic agent

KIT and PDGFRA mutant kinases inhibitorAntineoplastic agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
D
FDA category + note
Top interactionssee all 12 →
  • AbciximabSevereDatabaseDDInter
  • AcalabrutinibSevereDatabaseDDInter
  • AdalimumabSevereDatabaseDDInter
  • AlteplaseSevereDatabaseDDInter

Mechanism

Avapritinib is an orally bioavailable inhibitor of KIT and PDGFRA mutant kinases.

Indications

metastatic GIST harboring PDGFRA mutationsadvanced systemic mastocytosismast cell leukemiaAdvanced Systemic Mastocytosis (AdvSM)Mast Cell Leukemia (MCL)

Pharmacokinetics

Half-life
20 to 57 h
Metabolism
CYP3A (primarily)

Side effects

Serious
  • risk of intracranial hemorrhage
  • cognitive impairment

Pregnancy & lactation

Pregnancy

D

Drug interactions

Abciximab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Acalabrutinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Adalimumab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Alteplase
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Aminolevulinic Acid
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amprenavir
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Anagrelide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Anisindione
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Anistreplase
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Antithrombin Alfa
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Antithrombin Iii Human
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Apalutamide
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Related guidelines

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EULAR · Rheumatology · 2023
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RSSDI · Cardiology · 2023
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ICMR · Cardiology · 2019
Hypertrophic cardiomyopathy
ESC · Cardiology · 2026
Sjögren's syndrome
EULAR · Rheumatology · 2025

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Sources: Goodman & Gilman 14e, Harrison 22e·Verified: 2026-05-10 · House clinical team