Drug reference
benzathine penicillin
Drug monograph
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Not yet extracted
Indications
early syphilislate syphilisPrimary SyphilisEarly Syphilis (in HIV-infected persons)
Dosing
- Adult
- 2.4 MU i.m., 1–3 weekly inj. (for early syphilis); 2.4 MU i.m. weekly × 4 weeks (for late syphilis)
- Renal adjustment
- Not specified in this chapter.
Pharmacokinetics
Protein binding
Benzathine penicillin is administered in an insoluble form (s.c. and i.m. injection) to prolong its action by delaying absorption.
Related guidelines
Other Unclassified drugs
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Sources: KD Tripathi 7e, Harrison 22e·Verified: 2026-05-10 · House clinical team