Levacetylmethadol
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
brexanolone
Drug monograph
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
2 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactions
- LevacetylmethadolSevereDatabaseDDInter
- Sodium OxybateSevereDatabaseDDInter
Mechanism
Brexanolone is a neuroactive steroid that acts as a positive allosteric modulator (PAM) at GABAA receptors.
Indications
postpartum depression
Pharmacokinetics
Half-life
9 hours
Metabolism
alpha-keto reduction, glucuronidation, sulfation
Side effects
Common
sedationdizziness
Serious
- sudden loss of consciousness
Drug interactions
Sodium Oxybate
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
10 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Other Unclassified drugs
Ask House about brexanolone
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team