Carbamazepine
Severe
Textbook
Decreased cabotegravir plasma concentrations, leading to loss of efficacy.
Should not be coadministered.
Source: G&G 14e · p1245-1266
Drug reference
cabotegravir
Integrase Inhibitor · Antiretroviral
Integrase InhibitorAntiretroviral
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
9 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 9 →
- CarbamazepineSevereTextbookG&G 14e · p1245-1266
- RifamycinsSevereTextbookG&G 14e · p1245-1266
- St John S WortSevereTextbookG&G 14e · p1245-1266
- OxcarbazepineSevereDatabaseDDInter
Mechanism
Cabotegravir blocks the catalytic activity of the HIV-encoded integrase of HIV-1 and HIV-2, preventing the integration of viral DNA into the host chromosome. It interferes with essential divalent cations in the enzyme’s catalytic core.
Indications
HIV treatment in adults with chronically suppressed plasma HIV RNA who are stable on an antiretroviral regimen with no history of treatment failure and with no known or suspected resistance to cabotegravir or rilpivirine (in combination with LA rilpivirine)HIV prevention
Pharmacokinetics
Half-life
5.6 to 11.5 weeks (injectable nanoformulation)
Protein binding
99.8%
Metabolism
UGT1A1
Excretion
27% (renal, unchanged)
Side effects
Common
injection site reactionspyrexiafatigueheadachemusculoskeletal painhepatotoxicitydepressive symptoms
Drug interactions
Rifamycins
Severe
Textbook
Decreased cabotegravir plasma concentrations, leading to loss of efficacy.
Should not be coadministered.
Source: G&G 14e · p1245-1266
St John S Wort
Severe
Textbook
Decreased cabotegravir plasma concentrations, leading to loss of efficacy.
Should not be coadministered.
Source: G&G 14e · p1245-1266
Oxcarbazepine
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Phenobarbital
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Phenytoin
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Rifabutin
Severe
Database
Drug interaction classified as: others
Source: DDInter
Rifampicin
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Rifapentine
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
3 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Ask House about cabotegravir
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team