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capmatinib

MET kinase inhibitor · Antineoplastic agent

MET kinase inhibitorAntineoplastic agent
CDSCO approved
EXCRETION
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
D
FDA category + note
Top interactionssee all 12
  • Aminolevulinic AcidSevereDatabaseDDInter
  • AmprenavirSevereDatabaseDDInter
  • ApalutamideSevereDatabaseDDInter
  • AtazanavirSevereDatabaseDDInter

Mechanism

Capmatinib is an orally bioavailable selective inhibitor of the MET kinase.

Indications

metastatic NSCLC with a mutation that leads to MET exon 14 skipping

Pharmacokinetics

Half-life
6.5 h
Metabolism
CYP3A4 (predominantly)

Side effects

Common
peripheral edemadyspepsiafatigue

Pregnancy & lactation

Pregnancy

D

Drug interactions

Aminolevulinic Acid
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amprenavir
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Apalutamide
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Atazanavir
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Berotralstat
Severe
Database

Drug interaction classified as: absorption

Source: DDInter

Boceprevir
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Bosentan
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Carbamazepine
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Cenobamate
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Ceritinib
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Clarithromycin
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Cobicistat
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Related guidelines

Other MET kinase inhibitor drugs

Ask House about capmatinib

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team