Drug reference

cefoperazone

β-Lactam antibiotic · Antibacterial

β-Lactam antibioticAntibacterialATC null

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

3 major

SEVERE in our sources

PREGNANCY

FDA category + note

Top interactionssee all 9 →

AlcoholSevereTextbook-citedKDT 7e · p948
WarfarinSevereTextbook-citedKDT 7e · p948
RifampicinSevereDatabaseDDInter

Mechanism

null

Indications

Pseudomonas (UTI, enteritis)Pseudomonas (stronger activity than other third generation compounds)S. typhiB. fragilisSevere urinary, biliary, respiratory, skin-soft tissue infectionsTyphoidMeningitisSepticaemias

Pharmacokinetics

Half-life

2 hr

Excretion

primarily in bile

Side effects

Common

Hypoprothrombinaemic action (does not affect platelet function)Disulfiram-like reaction with alcoholGastrointestinal side effects (e.g., diarrhea)

Serious

Hypersensitivity reactions (rash to anaphylaxis)
Serum sickness
Stevens-Johnson syndrome
Nephropathy
Hematologic reactions (neutropenia, prolonged use)
Neurotoxicity (seizure, high doses, renal impairment)

Pregnancy & lactation

Pregnancy

Drug interactions

Alcohol

Severe

Textbook-cited

Disulfiram-like reaction: flushing, nausea, vomiting, headache, palpitations

Warn patient to completely avoid alcohol during and 48h after treatment

Source: KDT 7e · p948

Warfarin

Severe

Textbook-cited

Increased bleeding risk

Monitor INR and reduce anticoagulant dose

Source: KDT 7e · p948

Rifampicin

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Anticoagulation Therapy

Moderate

Textbook

May be associated with clinically significant bleeding among patients receiving anticoagulation.

Caution and monitoring of coagulation parameters are advised for patients on anticoagulation or with vitamin K deficiency.

Source: G&G 14e · p1158

Aminoglycosides (e.g., Gentamicin, Amikacin)

Moderate

Database

Increased risk of acute kidney injury and hearing impairment.

Monitor renal function (serum creatinine, BUN, urine output) and aminoglycoside serum levels closely. Adjust doses of both drugs as needed. Avoid concomitant use if possible, especially in patients with pre-existing renal impairment. Monitor for signs of ototoxicity.

Aspirin

Moderate

Database

Increased risk of bleeding.

Monitor for signs of bleeding. Use with caution, especially in patients with pre-existing coagulopathies or other risk factors for bleeding. Consider alternative analgesics if possible.

Furosemide

Moderate

Database

Increased risk of acute kidney injury.

Monitor renal function (serum creatinine, BUN, urine output) closely, especially in patients with pre-existing renal impairment or those receiving high doses. Adjust cefoperazone dose based on renal function if necessary. Ensure adequate hydration.

Source: DDInter

Heparin

Moderate

Database

Increased risk of bleeding.

Monitor for signs of bleeding. Use with caution, especially in patients with pre-existing coagulopathies or other risk factors for bleeding. Consider monitoring coagulation parameters if prolonged co-administration is necessary.

Source: DDInter

Probenecid

Moderate

Database

Increased serum levels of cefoperazone, potentially enhancing its therapeutic effect but also increasing the risk of dose-related adverse effects.

Generally, this interaction is not clinically significant for cefoperazone as it is primarily excreted in bile. However, in patients with significant biliary obstruction or severe hepatic impairment, probenecid could lead to higher systemic exposure. Monitor for increased adverse effects if co-administered in such patients.

Source: DDInter

3 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.