Drug reference
ceftazidime-avibactam
Cephalosporin–β-lactamase inhibitor combination · Antibacterial; Cephalosporin/β-Lactamase Inhibitor
Cephalosporin–β-lactamase inhibitor combinationAntibacterial; Cephalosporin/β-Lactamase Inhibitor
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
B
FDA category + note
Mechanism
Ceftazidime inhibits bacterial cell-wall synthesis. Avibactam inhibits a broader spectrum of β-lactamases, including ESBLs, AmpC β-lactamases, and some KPCs.
Side effects
Common
Gastrointestinal side effects (e.g., diarrhea)
Serious
- Hypersensitivity reactions (rash to anaphylaxis)
- Serum sickness
- Stevens-Johnson syndrome
- Nephropathy
- Hematologic reactions (neutropenia, prolonged use)
- Neurotoxicity (seizure, high doses, renal impairment)
Pregnancy & lactation
Pregnancy
B
Related guidelines
Other Cephalosporin–β-lactamase inhibitor combination drugs
Ask House about ceftazidime-avibactam
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Sources: Harrison 22e·Verified: 2026-05-10 · House clinical team