Siponimod
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
cevimeline
Muscarinic agonist · Muscarinic Agonist
Muscarinic agonistMuscarinic Agonist
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
1 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactions
- SiponimodSevereDatabaseDDInter
Mechanism
Has a long-lasting sialogogic action on lacrimal and salivary glands. Preferentially activates M1 and M3 receptors.
Indications
Xerostomia due to Sjögren syndrome
Dosing
- Adult
- 30 mg three times daily
Side effects
Common
Fewer side effects and better patient compliance than pilocarpine may be observed
Drug interactions
11 additional unreviewed or low-confidence interactions hidden because their provenance or source detail is insufficient.
Related guidelines
Empirical antimicrobial use in common syndromes
ICMR · Infectious Diseases · 2019
Acute coronary syndrome in chronic kidney disease
CSI · Cardiology · 2020
Sjögren's syndrome
EULAR · Rheumatology · 2025
Primary PCI for acute coronary syndrome
ESC · Cardiology · 2026
Irritable bowel syndrome
ISG · Gastroenterology · 2023
Ask House about cevimeline
Continue into a citation-backed clinical answer with the drug context already attached.
Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10