Amoxicillin
Moderate
Textbook
Used for prophylaxis of dirty/contaminated surgical wounds.
Source: KDT 7e · p701
Drug reference
clavulanate
Beta-lactamase inhibitor · Antibiotic (enhancer)
Beta-lactamase inhibitorAntibiotic (enhancer)ATC J01CA04
CDSCO approvedATC J01CA04
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Clavulanate is a beta-lactamase inhibitor that protects amoxicillin from degradation by bacterial beta-lactamase enzymes, thereby extending the spectrum of amoxicillin's activity against beta-lactamase-producing bacteria.
Indications
Small intestinal bacterial overgrowth (SIBO, in combination with amoxicillin)
Dosing
- Adult
- 875 mg (amoxicillin) twice daily (in combination with amoxicillin for SIBO, 10-day course).
Pharmacokinetics
Bioavailability
well absorbed by mouth
Side effects
Common
NauseaVomitingHeadache
Drug interactions
Related guidelines
Other Beta-lactamase inhibitor drugs
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Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10