Drug reference

Clofibrate

Fibrate · Unknown

FibrateUnknown

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

8 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactionssee all 10 →

AtorvastatinSevereDatabaseDDInter
FluvastatinSevereDatabaseDDInter
LovastatinSevereDatabaseDDInter
PitavastatinSevereDatabaseDDInter

Mechanism

Clofibrate functions as a ligand for Peroxisome Proliferator-Activated Receptor alpha (PPARα). Its activation of PPARα leads to increased expression of various transporters, including MRP3, MRP4, and MDR2 in the liver.

Dosing

Adult: Clofibrate (500mg/kg,. (600mg/day, 9 days). TCPOBOP (3mg/kg,. (75 mg/kg, 4 days)

Pharmacokinetics

Metabolism

Undergoes hydrolysis as a Phase I reaction.

Drug interactions

Atorvastatin

Severe

Database

Drug interaction classified as: others

Source: DDInter

Fluvastatin

Severe

Database

Drug interaction classified as: others

Source: DDInter

Lovastatin

Severe

Database

Drug interaction classified as: others

Source: DDInter

Pitavastatin

Severe

Database

Clinical effect not specified

Source: DDInter

Pravastatin

Severe

Database

Drug interaction classified as: others

Source: DDInter

Rosuvastatin

Severe

Database

Drug interaction classified as: others

Source: DDInter

Simvastatin

Severe

Database

Drug interaction classified as: others

Source: DDInter

Warfarin

Severe

Database

Enhanced effect of warfarin.

The text does not provide specific management guidance beyond identification of the interaction.

Source: DDInter

Sulfonylureas

Moderate

Textbook

Enhanced hypoglycemic effect of sulfonylureas, increasing risk of hypoglycemia.

Source: G&G 14e · p1034

Chenodeoxycholic Acid

Moderate

Database

Increase biliary cholesterol

Avoid concurrent for gallstone indication

Source: Kimi deep-research + Cla

2 additional unreviewed or low-confidence interactions hidden because their provenance or source detail is insufficient.

Other Fibrate drugs

Ask House about Clofibrate

Continue into a citation-backed clinical answer with the drug context already attached.

Open in workspace Ask House about this drug

Textbook-sourced·Updated: 2026-05-13