Atorvastatin
Severe
Database
Drug interaction classified as: others
Source: DDInter
Drug reference
Clofibrate
Fibrate · Unknown
FibrateUnknown
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
8 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 11 →
- AtorvastatinSevereDatabaseDDInter
- FluvastatinSevereDatabaseDDInter
- LovastatinSevereDatabaseDDInter
- PitavastatinSevereDatabaseDDInter
Mechanism
Clofibrate functions as a ligand for Peroxisome Proliferator-Activated Receptor alpha (PPARα). Its activation of PPARα leads to increased expression of various transporters, including MRP3, MRP4, and MDR2 in the liver.
Dosing
- Adult
- Clofibrate (500mg/kg,. (600mg/day, 9 days). TCPOBOP (3mg/kg,. (75 mg/kg, 4 days)
Pharmacokinetics
Metabolism
Undergoes hydrolysis as a Phase I reaction.
Drug interactions
Fluvastatin
Severe
Database
Drug interaction classified as: others
Source: DDInter
Lovastatin
Severe
Database
Drug interaction classified as: others
Source: DDInter
Pitavastatin
Severe
Database
Clinical effect not specified
Source: DDInter
Pravastatin
Severe
Database
Drug interaction classified as: others
Source: DDInter
Rosuvastatin
Severe
Database
Drug interaction classified as: others
Source: DDInter
Simvastatin
Severe
Database
Drug interaction classified as: others
Source: DDInter
Warfarin
Severe
Database
Enhanced effect of warfarin.
The text does not provide specific management guidance beyond identification of the interaction.
Source: DDInter
Sulfonylureas
Moderate
Textbook
Enhanced hypoglycemic effect of sulfonylureas, increasing risk of hypoglycemia.
Source: G&G 14e · p1034
Chenodeoxycholic Acid
Moderate
Database
Increase biliary cholesterol
Avoid concurrent for gallstone indication
Source: Kimi deep-research + Cla
Ursodeoxycholic Acid
Moderate
Database
Reduced efficacy of ursodeoxycholic acid in dissolving gallstones.
Avoid concomitant use if ursodeoxycholic acid is used for gallstone dissolution. If used for other indications, monitor for reduced efficacy.
1 additional low-confidence interaction hidden — those rows lack a documented mechanism or management plan in our sources.
Other Fibrate drugs
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