Drug reference
corticorelin
Synthetic CRH · Diagnostic agent
Synthetic CRHDiagnostic agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Upon CRH binding, the CRH receptor activates the Gs–adenylyl cyclase–cyclic AMP pathway within corticotrophs, ultimately stimulating both ACTH biosynthesis and secretion.
Indications
diagnostic testing of the HPA axisdifferentiating pituitary from ectopic ACTH sourcesdifferentiating pseudo-Cushing states from true Cushing syndromeperitumoral brain edema postsurgery (off-label use)
Related guidelines
Acute coronary syndrome in chronic kidney disease
CSI · Cardiology · 2020
Empirical antimicrobial use in common syndromes
ICMR · Infectious Diseases · 2019
Sjögren's syndrome
EULAR · Rheumatology · 2025
Acute coronary syndrome
CSI · Cardiology · 2022
Primary PCI for acute coronary syndrome
ESC · Cardiology · 2026
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Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10