Alimemazine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
deutetrabenazine
Drug monograph
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
C
FDA category + note
Top interactionssee all 12 →
- AlimemazineSevereDatabaseDDInter
- AmiodaroneSevereDatabaseDDInter
- AmisulprideSevereDatabaseDDInter
- AmoxapineSevereDatabaseDDInter
Mechanism
Deutetrabenazine is a VMAT2 inhibitor, which effectively lowers the vesicular storage and release of dopamine.
Indications
involuntary movement disordersHuntington’s choreatardive dyskinesiachorea of Huntington’s diseaseTreatment of chorea associated with HD
Dosing
- Adult
- Twice daily. Titration: 6 mg/week from starting dose of 6 mg twice daily to effective dosage range of 24–48 mg/day.
Side effects
Common
Well tolerated
Serious
- hypotension
- depression with suicidality
Pregnancy & lactation
Pregnancy
C
Lactation
Not specified
Drug interactions
Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amisulpride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amoxapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Anagrelide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Aripiprazole
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Arsenic Trioxide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Asenapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bedaquiline
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bepridil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Brexpiprazole
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bupropion
Severe
Database
Increased exposure to deutetrabenazine (~3-fold).
Adjust dose of deutetrabenazine for CYP2D6 status.
Source: DDInter
Related guidelines
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FOGSI · Obstetrics & Gynaecology · 2019
Substance use disorders
NIMHANS · Psychiatry · 2022
Other Unclassified drugs
Ask House about deutetrabenazine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team