Drug reference directory
Drug reference

dexfenfluramine

Appetite suppressant (withdrawn from market)

Appetite suppressant (withdrawn from market)
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
  • AlfentanilSevereDatabaseDDInter
  • AlmotriptanSevereDatabaseDDInter
  • AmitriptylineSevereDatabaseDDInter
  • AmoxapineSevereDatabaseDDInter

Mechanism

Promotes the release of 5HT and blocks its reuptake.

Side effects

Serious
  • Life-threatening heart valve disease
  • Pulmonary hypertension
  • Echocardiographic abnormalities
  • Valvular defects
  • Sudden deaths

Drug interactions

Alfentanil
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Almotriptan
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amitriptyline
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amoxapine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amphetamine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Benzphetamine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Bupropion
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Buspirone
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Citalopram
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Clomipramine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Cyclobenzaprine
Severe
Database

Clinical effect not specified

Source: DDInter

Desipramine
Severe
Database

Clinical effect not specified

Source: DDInter

Other Unclassified drugs

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Textbook-sourced·Sources: KD Tripathi 7e, Goodman & Gilman 14e·Updated: 2026-05-10