Tenofovir
Contraindicated
Textbook
Increased exposure to didanosine, potentially leading to increased toxicity.
The two drugs should not be used together.
Source: G&G 14e · p1245-1266
Drug reference
didanosine
Antiretroviral
Antiretroviral
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 12 →
- TenofovirContraindicatedTextbookG&G 14e · p1245-1266
- AllopurinolSevereDatabaseDDInter
- BexaroteneSevereDatabaseDDInter
- DolutegravirSevereDatabaseDDInter
Mechanism
Not yet extracted
Indications
HIV infection (use has declined due to higher toxicity)
Dosing
- Adult
- 400 mg/day (for > 60 kg BW), 250 mg/day (< 50 kg BW) 1 hour before or 2 hour after meals.
Pharmacokinetics
Half-life
1 to 1.5 hr
Bioavailability
38 ± 15%
Protein binding
<5%
Excretion
36 ± 9%
Side effects
Common
diarrhoeaabdominal paindry mouthnausea
Serious
- peripheral (stocking and glove) neuropathy (major dose-related toxicity, may be irreversible)
- acute pancreatitis (rarely)
Drug interactions
Allopurinol
Severe
Database
Drug interaction classified as: absorption
Source: DDInter
Bexarotene
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dolutegravir
Severe
Database
Clinical effect not specified
Source: DDInter
Hydroxyurea
Severe
Database
.
Source: DDInter
Leflunomide
Severe
Database
Clinical effect not specified
Source: DDInter
Lomitapide
Severe
Database
Clinical effect not specified
Source: DDInter
Methadone
Severe
Database
Clinical effect not specified
Source: DDInter
Mipomersen
Severe
Database
Clinical effect not specified
Source: DDInter
Pentamidine
Severe
Database
.
Source: DDInter
Pexidartinib
Severe
Database
Clinical effect not specified
Source: DDInter
Ribavirin
Severe
Database
Not specified, but combination should not be used.
Should not be used together. Avoid combination.
Source: DDInter
Related guidelines
Other Unclassified drugs
Ask House about didanosine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team