Adenosine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
digitoxin
Na+/K+ ATPase inhibitor · Positive inotropic agent, Antiarrhythmic
Na+/K+ ATPase inhibitorPositive inotropic agent, Antiarrhythmic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AdenosineSevereDatabaseDDInter
- AmiodaroneSevereDatabaseDDInter
- AtazanavirSevereDatabaseDDInter
- Calcium ChlorideSevereDatabaseDDInter
Mechanism
Not yet extracted
Indications
heart failureatrial fibrillation
Dosing
- Adult
- Plasma concentration: 10–25 ng/mL.
Pharmacokinetics
Half-life
7 days
Protein binding
Digitoxin has a half-life of 7 days.
Metabolism
Digitoxin is partially converted to digoxin.
Side effects
Common
nauseadiarrheavisual disturbances (altered color perception, coronas)
Serious
- proarrhythmic
Drug interactions
Amiodarone
Severe
Database
Drug interaction classified as: distribution.
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Calcium Chloride
Severe
Database
Clinical effect not specified
Source: DDInter
Calcium Glucoheptonate
Severe
Database
Clinical effect not specified
Source: DDInter
Calcium Gluconate
Severe
Database
Clinical effect not specified
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dolasetron
Severe
Database
Clinical effect not specified
Source: DDInter
Fingolimod
Severe
Database
Clinical effect not specified
Source: DDInter
Parathyroid Hormone
Severe
Database
Clinical effect not specified
Source: DDInter
Saquinavir
Severe
Database
Clinical effect not specified
Source: DDInter
Siponimod
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Ask House about digitoxin
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Textbook-sourced·Sources: KD Tripathi 7e, Goodman & Gilman 14e·Updated: 2026-05-10