Paliperidone
Moderate
Textbook
AUC of paliperidone increased by 50%.
Monitor for increased paliperidone effects.
Source: G&G 14e · p368
Drug reference
divalproex
Aliphatic carboxylic acid · Antiepileptic
Aliphatic carboxylic acidAntiepileptic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Divalproex is a coordination compound of valproic acid with sodium valproate (1:1). It acts as a prodrug, delivering valproic acid, which exerts broad-spectrum anticonvulsant action through multiple mechanisms including Na+ channel inactivation, T-current attenuation, and GABA potentiation.
Pharmacokinetics
Half-life
10-15 hours
Bioavailability
same as valproic acid
Protein binding
90% bound to plasma proteins
Metabolism
completely metabolized in liver by oxidation (mainly by CYP2C9 and 2C19, some metabolites are active) and glucuronide conjugation
Side effects
Common
gastric tolerance may be better
Drug interactions
11 additional unreviewed or low-confidence interactions hidden because their provenance or source detail is insufficient.
Related guidelines
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Textbook-sourced·Sources: KD Tripathi 7e·Updated: 2026-05-10