echinocandins

Echinocandins inhibit the synthesis of β-(1,3)-D-glucan, a key component of the fungal cell wall, leading to osmotic instability and cell lysis. Their effect appears to be to downmodulate the virulence of the fungus and reduce tissue necrosis and destruction from fungal invasion.

Adult

Standard echinocandin doses. Should be administered at standard, FDA-approved doses. Dose escalation of any echinocandin is not recommended because of a paradoxical loss of benefit of combination therapy at echinocandin doses of ≥3 mg/kg per day.