Drug reference

echothiophate

Organophosphate cholinesterase inhibitor · Antiglaucoma Agent (ophthalmic)

Organophosphate cholinesterase inhibitorAntiglaucoma Agent (ophthalmic)

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Echothiophate is an extremely potent choline derivative and organophosphorus compound. It inhibits acetylcholinesterase by forming a stable, phosphorylated conjugate with the active center serine.

Indications

glaucomaaccommodative esotropiaaccommodative strabismuslong acting miotic (formerly used)

Pharmacokinetics

Duration

Long-acting (implied by use as long-acting topical ChE inhibitor)

Bioavailability

As a positively charged quaternary amine, it is not volatile, does not readily penetrate the skin, and its quaternary ammonium group restricts entry into the CNS.