Droperidol
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
Enflurane
General Anesthetic · Anaesthetic
General AnestheticAnaesthetic
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
8 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 9 →
- DroperidolSevereDatabaseDDInter
- EpinephrineSevereDatabaseDDInter
- IsocarboxazidSevereDatabaseDDInter
- NorepinephrineSevereDatabaseDDInter
Mechanism
Enflurane has neuromuscular effects and may increase the potency and duration of neuromuscular blockade, particularly when used with neuromuscular blocking agents like vecuronium.
Indications
maintenance of anesthesia
Dosing
- Adult
- achieved. Absence of pungency makes it pleasant Injected i.v. (3–5 mg/kg) as a 2.5% solution,
Pharmacokinetics
Onset
relatively slow induction of anesthesia
Metabolism
Metabolized via CYP2E1
Contraindications
- patients with seizure disorders
- concerns over ability to decrease seizure threshold and potentially produce nephrotoxicity (limited clinical utility)
Side effects
Common
decrease in arterial blood pressure (vasodilation, myocardial contractility depression)effective bronchodilatorproduces a pattern of rapid shallow breathingrelaxes skeletal and uterine musclereduces renal blood flow, GFR, and urinary output
Serious
- can increase ICP
- can produce seizure activity
Drug interactions
Epinephrine
Severe
Database
Clinical effect not specified
Source: DDInter
Isocarboxazid
Severe
Database
Clinical effect not specified
Source: DDInter
Norepinephrine
Severe
Database
Clinical effect not specified
Source: DDInter
Phenelzine
Severe
Database
Clinical effect not specified
Source: DDInter
Selegiline
Severe
Database
Clinical effect not specified
Source: DDInter
Sodium Oxybate
Severe
Database
Clinical effect not specified
Source: DDInter
Tranylcypromine
Severe
Database
Clinical effect not specified
Source: DDInter
Isoniazid
Moderate
Database
Elevation of serum fluoride.
Not specified, but implies monitoring of fluoride levels or consideration of alternative anesthetics.
Source: DDInter
3 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Other General Anesthetic drugs
Ask House about Enflurane
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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team