Stiripentol
Severe
Textbook
The maximum daily maintenance dose of fenfluramine is reduced to 0.2 mg/kg twice daily when co-administered with stiripentol plus clobazam.
Dose adjustment of fenfluramine is required.
Source: G&G 14e · p399
Drug reference
fenfluramine
Appetite suppressant (withdrawn from market)
Appetite suppressant (withdrawn from market)
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- StiripentolSevereTextbookG&G 14e · p399
- AlfentanilSevereDatabaseDDInter
- AlmotriptanSevereDatabaseDDInter
- AmphetamineSevereDatabaseDDInter
Mechanism
Promotes the release of 5HT and blocks its reuptake.
Side effects
Serious
- Life-threatening heart valve disease
- Pulmonary hypertension
- Echocardiographic abnormalities
- Valvular defects
- Sudden deaths
Drug interactions
Alfentanil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Almotriptan
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amphetamine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Benzphetamine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bupropion
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Buspirone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Citalopram
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cyclobenzaprine
Severe
Database
Clinical effect not specified
Source: DDInter
Desvenlafaxine
Severe
Database
Clinical effect not specified
Source: DDInter
Dexfenfluramine
Severe
Database
Clinical effect not specified
Source: DDInter
Dextromethorphan
Severe
Database
Clinical effect not specified
Source: DDInter
Other Unclassified drugs
Ask House about fenfluramine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team