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fenoprofen

Propionic Acid Derivative, NSAID · Anti-inflammatory

Propionic Acid Derivative, NSAIDAnti-inflammatory
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
C
FDA category + note
Top interactionssee all 12 →
  • AcalabrutinibSevereDatabaseDDInter
  • Aminolevulinic AcidSevereDatabaseDDInter
  • AnisindioneSevereDatabaseDDInter
  • ApixabanSevereDatabaseDDInter

Mechanism

Fenoprofen is a nonselective COX inhibitor with effects and side effects common to other NSAIDs.

Indications

Symptomatic treatment of rheumatoid arthritisOsteoarthritisPain

Dosing

Adult
200 mg 4–6 times/day or 300–600 mg 3–4 times/day (max 3.2 g/day).

Pharmacokinetics

Half-life
2.5–3 h
Protein binding
99%
Metabolism
4-OH metabolite; glucuronide conjugates

Side effects

Common
15% experience side effects

Pregnancy & lactation

Pregnancy

C

Lactation

Excreted in breast milk.

Drug interactions

Acalabrutinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Aminolevulinic Acid
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Anisindione
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Apixaban
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Ardeparin
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Avapritinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Betrixaban
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Cabozantinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Cidofovir
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Dalteparin
Severe
Database

Clinical effect not specified

Source: DDInter

Danaparoid
Severe
Database

Clinical effect not specified

Source: DDInter

Dasatinib
Severe
Database

Clinical effect not specified

Source: DDInter

Related guidelines

Rheumatoid arthritis
IRA · Rheumatology · 2023
Knee osteoarthritis
MOHFW · Orthopaedics · 2021
Rheumatoid arthritis
EULAR · Rheumatology · 2022
Rheumatoid arthritis
ACR · Rheumatology · 2021
Low back pain and sciatica
NICE · Orthopaedics · 2020

Other Propionic Acid Derivative, NSAID drugs

oxaprozin
0 brands

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team