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oxaprozin

Propionic Acid Derivative, NSAID · Anti-inflammatory

Propionic Acid Derivative, NSAIDAnti-inflammatory
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
C
FDA category + note
Top interactionssee all 12 →
  • AcalabrutinibSevereDatabaseDDInter
  • AnisindioneSevereDatabaseDDInter
  • ApixabanSevereDatabaseDDInter
  • ArdeparinSevereDatabaseDDInter

Mechanism

Oxaprozin is a nonselective COX inhibitor with effects and side effects common to other NSAIDs. It has a slow onset of action.

Indications

Symptomatic treatment of rheumatoid arthritisOsteoarthritisJuvenile arthritis

Dosing

Adult
600–1200 mg daily (maximum 1800 mg).
Pediatric
Children >21 kg: 600–1200 mg daily based on weight (maximum 1200 mg).
Geriatric
Dose adjusted based on weight.

Pharmacokinetics

Half-life
41–55 h
Protein binding
99%
Metabolism
65% oxidates, 35% glucuronides

Pregnancy & lactation

Pregnancy

C

Lactation

Expected to be excreted in breast milk.

Drug interactions

Acalabrutinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Anisindione
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Apixaban
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Ardeparin
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Avapritinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Betrixaban
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Cabozantinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Cidofovir
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Dalteparin
Severe
Database

Clinical effect not specified

Source: DDInter

Danaparoid
Severe
Database

Clinical effect not specified

Source: DDInter

Dasatinib
Severe
Database

Clinical effect not specified

Source: DDInter

Deferasirox
Severe
Database

Clinical effect not specified

Source: DDInter

Related guidelines

Rheumatoid arthritis
IRA · Rheumatology · 2023
Knee osteoarthritis
MOHFW · Orthopaedics · 2021
Rheumatoid arthritis
EULAR · Rheumatology · 2022
Rheumatoid arthritis
ACR · Rheumatology · 2021
Inflammatory bowel disease
OTHER · Gastroenterology · 2015

Other Propionic Acid Derivative, NSAID drugs

fenoprofen
0 brands

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team