Drug reference

Ferric carboxymaltose

Iron Supplement · Haematinic

Iron SupplementHaematinicATC B03AC

CDSCO approvedSchedule HATC B03AC

EXCRETION

—

not curated

INTERACTIONS

2 major

SEVERE in our sources

PREGNANCY

and used in the second or third

FDA category + note

Top interactions

DimercaprolSevereDatabaseDDInter
ErdafitinibSevereDatabaseDDInter

Mechanism

Ferric carboxymaltose is a colloidal iron preparation embedded within a carbohydrate polymer. It provides a source of iron for the synthesis of hemoglobin and replenishment of iron stores, particularly when oral iron therapy is unsuccessful due to intolerance, poor absorption, or ongoing blood loss.

Indications

Iron deficiency when oral therapy is unsuccessful (e.g., patient cannot tolerate oral iron, does not take it reliably, continuing blood loss, malabsorption)Management of chemotherapy-induced anaemia (when given with erythropoietins)Chronic renal failure patients (including those on haemodialysis or peritoneal dialysis) requiring intravenous ironAnaemia patients for rapid increase in haemoglobin level and replenishment of storesiron deficiency in heart failure (NYHA class II–III, hemoglobin levels of 9.5 to 13.5 g/dL)iron deficiency anemia in patients with intolerance to oral ironiron deficiency anemia in patients with unsatisfactory response to oral ironiron deficiency anemia in patients with non–dialysis-dependent chronic kidney diseaseIron deficiency anaemiaWhen oral iron is not toleratedFailure to absorb oral iron (malabsorption, inflammatory bowel disease, chronic inflammation)Non-compliance to oral ironSevere deficiency with chronic bleedingAlong with erythropoietin (to meet demands of induced rapid erythropoiesis)

Dosing

Adult: iron is given as a total dose or in divided doses. Further treatment should be guided by monitoring haemoglobin and serum iron concentrations.…
Pediatric: not recommended for children <14 years

Contraindications

Serious hypersensitivity reactions to intravenous iron, including life-threatening and fatal anaphylactic reactions
Iron overload (due to parenteral administration bypassing regulatory mechanisms)
i.m. injection

Side effects

Common

Pain at injection siteRashesHeadacheNauseaAbdominal painHypotension (infrequent)Flushing (infrequent)Chest pain (infrequent)dizzinessconstipationdiarrhearashinjection site reactions

Serious