Berotralstat
Severe
Database
Drug interaction classified as: absorption
Source: DDInter
Drug reference
Fidaxomicin
Antibacterial · Antibiotic (for Clostridioides difficile infection)
Also known as Dificid
AntibacterialAntibiotic (for Clostridioides difficile infection)
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
3 major
SEVERE in our sources
PREGNANCY
Manufacturer advises avoid—no information available.
FDA category + note
Top interactions
- BerotralstatSevereDatabaseDDInter
- RelugolixSevereDatabaseDDInter
- VenetoclaxSevereDatabaseDDInter
Mechanism
Fidaxomicin is a macrocyclic antibacterial. It is poorly absorbed from the gastro-intestinal tract, limiting its action to the gut lumen. This characteristic makes it unsuitable for treating systemic infections.
Indications
Clostridioides difficile infectionSevere or life-threatening Clostridioides difficile infectionColitis caused by C difficile
Dosing
- Adult
- 200 mg every 12 hours for 10 days (by mouth)
Pharmacokinetics
Bioavailability
Poorly absorbed from the gastro-intestinal tract
Side effects
Common
ConstipationNauseaVomiting
Serious
- Angioedema
- Dyspnoea
- Hypersensitivity
Pregnancy & lactation
Pregnancy
Manufacturer advises avoid—no information available.
Lactation
Manufacturer advises avoid—no information available.
Drug interactions
Relugolix
Severe
Database
Drug interaction classified as: absorption
Source: DDInter
Venetoclax
Severe
Database
Drug interaction classified as: absorption
Source: DDInter
9 additional unreviewed or low-confidence interactions hidden because their provenance or source detail is insufficient.
Related guidelines
Other Antibacterial drugs
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Textbook-sourced·Sources: Goodman & Gilman 14e, Katzung, BNF, Harriet Lane·Updated: 2026-05-10