Berotralstat
Severe
Database
Drug interaction classified as: absorption
Source: DDInter
Drug reference
Fidaxomicin
Antibacterial · Antibiotic (for Clostridioides difficile infection)
Also known as Dificid
AntibacterialAntibiotic (for Clostridioides difficile infection)
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
3 major
SEVERE in our sources
PREGNANCY
Manufacturer advises avoid—no information available.
FDA category + note
Top interactions
- BerotralstatSevereDatabaseDDInter
- RelugolixSevereDatabaseDDInter
- VenetoclaxSevereDatabaseDDInter
Mechanism
Fidaxomicin is a macrocyclic antibacterial. It is poorly absorbed from the gastro-intestinal tract, limiting its action to the gut lumen. This characteristic makes it unsuitable for treating systemic infections.
Indications
Clostridioides difficile infectionSevere or life-threatening Clostridioides difficile infectionColitis caused by C difficile
Dosing
- Adult
- 200 mg every 12 hours for 10 days (by mouth)
Pharmacokinetics
Bioavailability
Poorly absorbed from the gastro-intestinal tract
Side effects
Common
ConstipationNauseaVomiting
Serious
- Angioedema
- Dyspnoea
- Hypersensitivity
Pregnancy & lactation
Pregnancy
Manufacturer advises avoid—no information available.
Lactation
Manufacturer advises avoid—no information available.
Drug interactions
Relugolix
Severe
Database
Drug interaction classified as: absorption
Source: DDInter
Venetoclax
Severe
Database
Drug interaction classified as: absorption
Source: DDInter
9 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Other Antibacterial drugs
Ask House about Fidaxomicin
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Katzung, BNF, Harriet Lane·Verified: 2026-05-10 · House clinical team