Drug reference

Methicillin

Antibacterial · Antibiotic

AntibacterialAntibiotic

CDSCO approvedSchedule H1

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Methicillin's mechanism of action involves inhibiting bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). Resistance in Staphylococcus aureus (MRSA) occurs due to the acquisition of a low-affinity penicillin-binding protein 2' (PBP2a), which reduces the drug's effectiveness.

Dosing

Adult: Adult: Initially 800 micrograms daily in divided doses, increased in steps of 400–800 micrograms daily (max. per dose 800 micrograms) as required recommended duration of treatment 7–10 days if no opioid use (but longer may be required); maximum 2.4 mg per day l MEDICINAL FORMS No licensed medicines listed.…