Drug monograph
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Sucralfate contains aluminum which chelates fluoroquinolones in the GI tract, reducing absorption by 85-90% and rendering the antibiotic ineffective.
Separate administration by at least 6 hours. Give fluoroquinolone 2 hours BEFORE or 6 hours AFTER sucralfate. Monitor clinical response to antibiotic.
Source: Kimi deep-research + Cla · p656
Decreased absorption of fluoroquinolones.
Stagger administration of antacids and fluoroquinolones by 2 hours.
Source: KDT 7e · p656
Increased risk of hypoglycemia.
Not explicitly stated, but implies close monitoring of blood glucose.
Source: G&G 14e · p571
Increased risk of cardiotoxicity and arrhythmias.
Monitor QTc.
Source: Harrison 22e · p1172
Decreased oral absorption of fluoroquinolones.
Administer fluoroquinolone 2 h before or 6 h after interacting drug.
Source: Harrison 22e · p1172
Additive tendon toxicity
Avoid combination, esp. elderly
Source: Kimi deep-research + Cla
Iron-quinolone chelation
Separate by ≥2 h
Source: Kimi deep-research + Cla
1 additional unreviewed or low-confidence interaction hidden because their provenance or source detail is insufficient.
Continue into a citation-backed clinical answer with the drug context already attached.
Textbook-sourced·Sources: KD Tripathi 7e·Updated: 2026-05-10