Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Flutamide
Androgen · Anti-neoplastic agent
AndrogenAnti-neoplastic agentATC null
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
In first trimester, high doses associated with
FDA category + note
Top interactionssee all 12 →
- AmiodaroneSevereDatabaseDDInter
- AmisulprideSevereDatabaseDDInter
- AnagrelideSevereDatabaseDDInter
- Arsenic TrioxideSevereDatabaseDDInter
Mechanism
Flutamide is an androgen receptor antagonist that inhibits the binding of androgens to the androgen receptor. When used in conjunction with GnRH analogs, it blocks the action of adrenal androgens, which are not inhibited by GnRH analogs. Increased LH secretion can stimulate higher serum testosterone concentrations when used alone, limiting efficacy.
Indications
Advanced prostate cancerMetastatic prostate cancer refractory to gonadorelin analogue therapy (monotherapy)Metastatic prostate cancer (in conjunction with a GnRH analog)Hirsutism in women (off-label)Familial GnRH-independent sexual precocity with premature Leydig cell maturation (in combination with testolactone)hirsutismAll forms of advanced prostate cancer (used infrequently due to unfavorable toxicity profile)metastatic carcinoma prostate (as part of combined androgen blockade therapy)Metastatic prostate cancer
Dosing
- Adult
- l INDICATIONS AND DOSE Breast cancer in postmenopausal women ▶ BY MOUTH ▶ Adult: 10–20 mg daily Prostate cancer ▶ BY MOUTH CAUTIONARY AND ADVISORY LABELS 25 ▶ BNF 80 Xtandi (Astellas Pharma Ltd) Enzalutamide 40 mg Xtandi 40mg tablets | 112 tablet P £2,734.67 ▶ Adult: 1–3 mg daily Cardiovascular disease Bone pain (in breast cancer) . breast abnormalities . cervical mucus increased .…
Pharmacokinetics
Half-life
Half-life of 5 hours.
Metabolism
Metabolized by CYP1A2
Contraindications
- Hepatic toxicity
- pregnancy (due to potential impaired virilization of male fetus)
Side effects
Common
DiarrheaBreast tendernessNipple tendernessNausea (less commonly)Vomiting (less commonly)gynaecomastia
Serious
- Hepatic toxicity
- Hepatotoxicity (less commonly)
- Fatal hepatotoxicity (rare reports)
- hepatotoxicity
Pregnancy & lactation
Pregnancy
In first trimester, high doses associated with
Drug interactions
Amisulpride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Anagrelide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Arsenic Trioxide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bedaquiline
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bepridil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cabozantinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cisapride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Citalopram
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clozapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Crizotinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Other Androgen drugs
Ask House about Flutamide
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, BNF·Verified: 2026-05-13 · House clinical team