Drug reference

Glutaraldehyde

Antiseptic · Antiverruca agent

AntisepticAntiverruca agent

CDSCO approvedOTC

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

Avoid (toxicity in animal studies).

FDA category + note

Mechanism

While its exact mechanism of action is not known, non-clinical studies indicate that Glutaraldehyde inhibits the growth of activated keratinocytes and exhibits anti-oxidative effects at the site of application.

Indications

Warts (external genital and perianal) in immunocompetent patientsWarts on hands and feetdisinfect surgical instrumentsdisinfect endoscopes

Dosing

Adult: Apply up to 250 mg topically 3 times a day until complete clearance of warts (maximum 16 weeks).
Hepatic adjustment: Avoid in severe impairment.
Max dose: 750 mg per day

Contraindications

Broken skin
Contact with eyes
Contact with lips
Contact with mouth
Contact with nostrils
Inflamed skin
Uncircumcised males (risk of phimosis)
Vulvar region

Side effects

Common

BalanoposthitisIncreased risk of infectionLymphatic abnormalitiesNecrosisPainful sexual intercoursePhimosisSkin reactionsUrinary disorderssensitization (on repeated application to skin)

Serious