Drug reference

gnrh

Gonadotropin-releasing hormone · Hormone, diagnostic agent

Gonadotropin-releasing hormoneHormone, diagnostic agent

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

GnRH is a hypothalamic decapeptide that stimulates pituitary gonadotropin production (LH and FSH) when secreted pulsatilely. It signals through a unique GPCR on gonadotropes, leading to increased LH and FSH secretion and expression of glycoprotein hormone subunit genes.

Indications

Induction of sexual maturation (if fertility is the goal)

Dosing

Adult: Intermittent release is crucial for proper synthesis and release of gonadotropins; continuous administration leads to desensitization and downregulation of GnRH receptors.