Tizanidine
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
guanethidine
Drug monograph
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
1 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 3 →
- TizanidineSevereDatabaseDDInter
Mechanism
Not yet extracted
Indications
Antihypertensive (historically, no longer in use)
Pharmacokinetics
Protein binding
Guanethidine is a 'hit and run' drug, meaning its effect lasts much longer than the drug itself.
Side effects
Serious
- marked side effects
Drug interactions
Minoxidil
Moderate
Database
Additive hypotensive effect; orthostatic hypotension risk
Monitor BP closely; adjust doses
Source: Kimi deep-research + Cla
Xylometazoline
Moderate
Database
Increased blood pressure, reduced efficacy of guanethidine.
Use with caution. Monitor blood pressure closely. Consider alternative decongestants. Guanethidine is rarely used now, but the interaction mechanism is relevant.
9 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Other Unclassified drugs
Ask House about guanethidine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team