Tizanidine
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
guanethidine
Drug monograph
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
1 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 2 →
- TizanidineSevereDatabaseDDInter
Mechanism
Not yet extracted
Indications
Antihypertensive (historically, no longer in use)
Pharmacokinetics
Protein binding
Guanethidine is a 'hit and run' drug, meaning its effect lasts much longer than the drug itself.
Side effects
Serious
- marked side effects
Drug interactions
Minoxidil
Moderate
Database
Additive hypotensive effect; orthostatic hypotension risk
Monitor BP closely; adjust doses
Source: Kimi deep-research + Cla
10 additional unreviewed or low-confidence interactions hidden because their provenance or source detail is insufficient.
Related guidelines
Other Unclassified drugs
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Textbook-sourced·Sources: KD Tripathi 7e·Updated: 2026-05-10