Drug reference
hexamethonium
Ganglionic blocking agent (Nn receptor antagonist) · Research tool (historical antihypertensive)
Ganglionic blocking agent (Nn receptor antagonist)Research tool (historical antihypertensive)
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Blocks the channel after it opens, shortening the duration of current flow by either occluding the open channel or causing it to close. This blocks the initial EPSP and inhibits ganglionic transmission.
Side effects
Serious
- Numerous undesirable side effects due to generalized ganglionic blockade
Related guidelines
Other Ganglionic blocking agent (Nn receptor antagonist) drugs
Ask House about hexamethonium
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team