Tizanidine
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
trimethaphan
Ganglionic blocking agent (Nn receptor antagonist) · Antihypertensive (historical use)
Ganglionic blocking agent (Nn receptor antagonist)Antihypertensive (historical use)
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
1 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactions
- TizanidineSevereDatabaseDDInter
Mechanism
Impairs ganglionic transmission by competition with acetylcholine at the Nn receptor.
Indications
Induction of controlled hypotension during surgery (historical use)Rapid reduction of blood pressure in hypertensive emergencies (historical use)Controlled hypotension (occasionally infused i.v.)Hypertensive emergency (due to aortic dissection)Hypertensive emergencies
Side effects
Serious
- Numerous undesirable side effects due to generalized ganglionic blockade
Drug interactions
11 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Other Ganglionic blocking agent (Nn receptor antagonist) drugs
Ask House about trimethaphan
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team