Intravenous Anaesthetics
Moderate
Textbook
Delirium, convulsions, and other excitatory effects during recovery from intravenous anaesthetics.
Excitatory effects are generally suppressed by opioids.
Source: KDT 7e · p385
Drug reference
Hyoscine
Antimuscarinic · Symptom control
Also known as Hyoscine hydrobromide, Hyoscine butylbromide
AntimuscarinicSymptom control
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Hyoscine is an antimuscarinic drug used to reduce bowel colic and excessive respiratory secretions.
Indications
Bowel colicExcessive respiratory secretionsGastro-intestinal pain (bowel colic)Motion sickness (prophylactic)Sedation and amnesia during labour (historical use)Control of maniacal states (historical use)motion sickness
Dosing
- Adult
- Subcutaneous injection: generally every 4 hours as required; hourly use may be necessary for excessive respiratory secretions. If symptoms persist, can be given regularly via a continuous infusion device. Hyoscine hydrobromide can also be given sublingually (e.g., Kwells® tablets) for bowel colic.
Pharmacokinetics
Onset
Administration before symptoms have set in is more effective for motion sickness.
Protein binding
Not specified, but has better blood-brain barrier penetration than atropine.
Metabolism
more completely metabolized
Side effects
Common
Dry mouthSedationAmnesiaFatigueDrowsinessN-REM sleep (low doses)Excitation (high doses)other anticholinergic side effects
Drug interactions
Related guidelines
Inflammatory bowel disease
OTHER · Gastroenterology · 2015
Gastro-oesophageal reflux disease
ISG · Gastroenterology · 2022
Induction of labour
FOGSI · Obstetrics & Gynaecology · 2019
Preventive care in inflammatory bowel disease
ACG · Gastroenterology · 2025
Irritable bowel syndrome
ISG · Gastroenterology · 2023
Other Antimuscarinic drugs
Ask House about Hyoscine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Katzung, BNF, Harriet Lane·Verified: 2026-05-10 · House clinical team