Potassium Chloride
Severe
Database
.
Source: DDInter
Drug reference
hyoscyamine
Belladonna alkaloid, muscarinic antagonist · Anticholinergic
Belladonna alkaloid, muscarinic antagonistAnticholinergicATC A03BA03
CDSCO approvedATC A03BA03
EXCRETION
—
not curated
INTERACTIONS
4 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactions
- Potassium ChlorideSevereDatabaseDDInter
- Potassium CitrateSevereDatabaseDDInter
- TopiramateSevereDatabaseDDInter
- ZonisamideSevereDatabaseDDInter
Mechanism
Not yet extracted
Indications
Diarrhea-predominant irritable bowel syndrome (IBS)Increased tone and motility of the GI tract (spasticity)Diarrhea associated with irritation of the lower bowel (e.g., mild dysenteries, diverticulitis)IBS (to prevent pain and fecal urgency)
Dosing
- Adult
- Sublingual tablets, orally disintegrating tablets, immediate-release oral capsules, tablets, elixir, and drops: 0.125–0.25 mg every 4 h as needed. Extended-release forms: 0.25–0.375 mg every 12 h, or 0.375 mg every 8 h, as needed. Injection (IM, IV, SC): 0.25–0.5 mg every 4 h as needed.
Contraindications
- Urinary tract obstruction
- GI obstruction
- Uncontrolled angle-closure glaucoma
- Benign prostatic hyperplasia (use with extreme caution)
- Colitis
- Reflux esophagitis
- Bowel obstruction
Side effects
Common
Antimuscarinic adverse effects similar to atropineDry mouthConstipationBlurred visionGastrointestinal discomfortCognitive impairmentDizzinessNausea
Drug interactions
Potassium Citrate
Severe
Database
Clinical effect not specified
Source: DDInter
Topiramate
Severe
Database
.
Source: DDInter
Zonisamide
Severe
Database
Clinical effect not specified
Source: DDInter
8 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Irritable bowel syndrome
ISG · Gastroenterology · 2023
Preventive care in inflammatory bowel disease
ACG · Gastroenterology · 2025
Empirical antimicrobial use in common syndromes
ICMR · Infectious Diseases · 2019
Acute coronary syndrome in chronic kidney disease
CSI · Cardiology · 2020
Inflammatory bowel disease
OTHER · Gastroenterology · 2015
Ask House about hyoscyamine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team