Alfentanil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
lemborexant
Orexin Receptor Antagonist · Hypnotic
Orexin Receptor AntagonistHypnotic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AlfentanilSevereDatabaseDDInter
- AmiodaroneSevereDatabaseDDInter
- AmlodipineSevereDatabaseDDInter
- AmprenavirSevereDatabaseDDInter
Mechanism
Lemborexant is another orexin 1/2 receptor antagonist, which promotes sleep by antagonizing wakefulness-promoting orexin signaling.
Indications
Insomnia
Dosing
- Adult
- Doses ranging from 2.5 to 10 mg
Pharmacokinetics
Half-life
17 to 19 h
Side effects
Common
Somnolence (especially at higher doses)Morning sedation
Serious
- Hypnagogic hallucinations
- Sleep paralysis
Drug interactions
Amiodarone
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Amlodipine
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Amprenavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Aprepitant
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Benzhydrocodone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Berotralstat
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Bicalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Boceprevir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Buprenorphine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Butorphanol
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Other Orexin Receptor Antagonist drugs
Ask House about lemborexant
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Harrison 22e·Verified: 2026-05-10 · House clinical team