Alfentanil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
suvorexant
Orexin Receptor Antagonist · Hypnotic
Orexin Receptor AntagonistHypnotic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AlfentanilSevereDatabaseDDInter
- AmprenavirSevereDatabaseDDInter
- ApalutamideSevereDatabaseDDInter
- AprepitantSevereDatabaseDDInter
Mechanism
Suvorexant is an inhibitor of orexin 1 and 2 receptors. Orexins promote wakefulness, so their antagonists enhance REM and non-REM sleep.
Indications
Insomniamay reduce relapse drinking by treating sleep disruptions commonly found in alcohol use disorder
Dosing
- Adult
- One 10-mg dose should be taken within 30 min of going to bed if at least 7 h remain until the projected time of awakening.
Side effects
Common
Daytime somnolenceMorning sedation
Serious
- Worsening of depression or suicidal ideation
- Hypnagogic hallucinations
- Sleep paralysis
Drug interactions
Amprenavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Apalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Aprepitant
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Benzhydrocodone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Berotralstat
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Boceprevir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Buprenorphine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Butorphanol
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Carbamazepine
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Related guidelines
Alcohol use disorder
MOHFW · Psychiatry · 2021
Substance use disorders
NIMHANS · Psychiatry · 2022
Hypertensive disorders of pregnancy
FOGSI · Obstetrics & Gynaecology · 2019
Generalised anxiety disorder and panic disorder
NICE · Psychiatry · 2020
Chronic kidney disease — mineral and bone disorder
KDIGO · Nephrology · 2017
Other Orexin Receptor Antagonist drugs
Ask House about suvorexant
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Textbook-sourced·Sources: Goodman & Gilman 14e, Harrison 22e·Updated: 2026-05-10