Amitriptyline
Severe
Textbook
Increased cardiotoxicity (e.g., QT prolongation).
Source: Harrison 22e · p1740
Drug reference
meglumine antimoniate
Antileishmanial agent
Antileishmanial agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
8 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 8 →
- AmitriptylineSevereTextbookHarrison 22e · p1740
- AmoxapineSevereTextbookHarrison 22e · p1740
- ClomipramineSevereTextbookHarrison 22e · p1740
- DesipramineSevereTextbookHarrison 22e · p1740
Mechanism
Not yet extracted
Pharmacokinetics
Half-life
<2 h (first phase); nearly 36 h (terminal phase)
Side effects
Common
arthralgiasmyalgiaspancreatitisecg changes (qt prolongation, t-wave flattening or inversion)
Drug interactions
Amoxapine
Severe
Textbook
Increased cardiotoxicity (e.g., QT prolongation).
Source: Harrison 22e · p1740
Clomipramine
Severe
Textbook
Increased cardiotoxicity (e.g., QT prolongation).
Source: Harrison 22e · p1740
Desipramine
Severe
Textbook
Increased cardiotoxicity (e.g., QT prolongation).
Source: Harrison 22e · p1740
Doxepin
Severe
Textbook
Increased cardiotoxicity (e.g., QT prolongation).
Source: Harrison 22e · p1740
Imipramine
Severe
Textbook
Increased cardiotoxicity (e.g., QT prolongation).
Source: Harrison 22e · p1740
Mirtazapine
Severe
Textbook
Increased cardiotoxicity (e.g., QT prolongation).
Source: Harrison 22e · p1740
Nortriptyline
Severe
Textbook
Increased cardiotoxicity (e.g., QT prolongation).
Source: Harrison 22e · p1740
Other Unclassified drugs
Ask House about meglumine antimoniate
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Harrison 22e·Verified: 2026-05-10 · House clinical team