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Drug reference

miglitol

α-Glucosidase inhibitor · Antidiabetic agent

α-Glucosidase inhibitorAntidiabetic agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
1 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactions
  • GatifloxacinSevereDatabaseDDInter

Mechanism

Miglitol reduces the intestinal absorption of starch, dextrin, and disaccharides by inhibiting the action of α-glucosidase in the intestinal brush border. This slows down carbohydrate digestion and absorption, reducing postprandial glucose excursions.

Indications

Adjunct to diet and exercise in type 2 diabetesUsed in combination with other oral antidiabetic agents or insulintype 2 diabetes mellitus

Dosing

Adult
25–100 mg three times daily (at the beginning of each meal)

Pharmacokinetics

Bioavailability
Substantial, but variable absorption
Metabolism
Not specified
Excretion
Almost entirely by the kidney

Side effects

Common
MalabsorptionFlatulenceDiarrheaAbdominal bloating
Serious
  • Cutaneous hypersensitivity (rare)

Drug interactions

Gatifloxacin
Severe
Database

Clinical effect not specified

Source: DDInter

11 additional unreviewed or low-confidence interactions hidden because their provenance or source detail is insufficient.

Related guidelines

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Textbook-sourced·Sources: KD Tripathi 7e, Goodman & Gilman 14e·Updated: 2026-05-10