Drug reference

n-acetylcysteine

Drug monograph

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

N-acetylcysteine replenishes depleted glutathione (GSH), permitting detoxification of excess N-acetyl-p-benzoquinone imine (NAPQI) before it can cause cellular damage.

Indications

Acetaminophen toxicity

Drug interactions

Chromium

Moderate

Textbook

Limits bioavailability and increases urinary excretion of chromium.

Reductants such as ascorbate, glutathione, or N-acetylcysteine, and ethylenediaminetetraacetic acid (EDTA), can be used to increase urinary excretion of chromium after high-dose exposure, particularly if given soon enough to prevent uptake into cells.

Source: G&G 14e · p1521