Cilostazole
Contraindicated
Textbook
Increased plasma levels and toxicity of cilostazole.
Should not be administered along with inhibitors of CYP3A4.
Source: KDT 7e · p555
Drug reference
Nefazodone
Atypical Antidepressant · Antidepressant
Also known as SERZONE
Atypical AntidepressantAntidepressant
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 12 →
- CilostazoleContraindicatedTextbookKDT 7e · p555
- AbemaciclibSevereDatabaseDDInter
- AcalabrutinibSevereDatabaseDDInter
- AlfentanilSevereDatabaseDDInter
Mechanism
Nefazodone primarily exerts its effects through modulation of serotonin (5-HT) systems. It also functions as an inhibitor of cytochrome P450 enzymes, specifically CYP2B6 and CYP3A4.
Indications
Depressionanxiety disorders
Dosing
- Adult
- 200–400 mg/day orally
Pharmacokinetics
Half-life
2-4 hours (parent), 1.5-4 hours (hydroxynefazodone metabolite)
Metabolism
Nefazodone inhibits CYP2B6 and CYP3A4 enzymes.
Side effects
Common
AgitationSeizuresSedationHypotension
Serious
- GI Effects
- liver failure (rare, resulted in voluntary withdrawal in several countries)
- hepatotoxicity (black-box warning)
- serotonin syndrome (with MAOIs)
Drug interactions
Abemaciclib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Acalabrutinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Alfentanil
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Alfuzosin
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Almotriptan
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alprazolam
Severe
Database
Significantly increased alprazolam plasma concentrations, leading to enhanced sedative and psychomotor effects.
Avoid concomitant use. If co-administration is unavoidable, reduce alprazolam dose by 50-75% and monitor for increased sedation.
Source: DDInter
Amitriptyline
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Amoxapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Artemether
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Astemizole
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Avanafil
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Related guidelines
Other Atypical Antidepressant drugs
Ask House about Nefazodone
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Katzung, Harriet Lane·Verified: 2026-05-10 · House clinical team