Lithium
Moderate
Textbook
Reduced pressor effect of noradrenaline.
Not explicitly stated
Source: KDT 7e
Drug reference
noradrenaline
Direct sympathomimetic · Pressor agent
Direct sympathomimeticPressor agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Noradrenaline acts as an agonist on α1, α2, β1, and β3 adrenoceptors, but has no β2 action. It causes a rise in systolic, diastolic, and mean BP by vasoconstriction, and increases heart rate and cardiac output.
Dosing
- Adult
- 2–4 µg/min i.v. infusion
Pharmacokinetics
Duration
Action starts declining within 5 min of discontinuing infusion.
Side effects
Serious
- Local tissue necrosis (if solution extravasates)
Drug interactions
Related guidelines
Other Direct sympathomimetic drugs
Ask House about noradrenaline
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Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team