Drug reference

olaratumab

human IgG1 monoclonal antibody, PDGFRα inhibitor · anticancer

human IgG1 monoclonal antibody, PDGFRα inhibitoranticancer

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

12 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactionssee all 12 →

AdalimumabSevereDatabaseDDInter
BaricitinibSevereDatabaseDDInter
CertolizumabSevereDatabaseDDInter
CladribineSevereDatabaseDDInter

Mechanism

Olaratumab is a human IgG1 monoclonal antibody that binds to PDGFRα and blocks ligand-mediated receptor activation.

Indications

soft-tissue sarcoma (in combination with doxorubicin) for adult patients with a histological subtype for which an anthracycline-containing regimen is appropriate and which is not amenable to curative treatment with radiotherapy or surgery

Side effects

Common

nauseafatigueneutropeniamusculoskeletal painmucositisalopeciavomitingdiarrheadecreased appetiteabdominal painneuropathyheadache

Serious

lymphopenia
neutropenia
thrombocytopenia
hyperglycemia
elevated activated partial thromboplastin time
hypokalemia
hypophosphatemia
infusion-related reactions (low blood pressure, fever, chills, rashes)
embryofetal harm

Drug interactions

Adalimumab

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Baricitinib

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Certolizumab

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Cladribine

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Deferiprone

Severe

Database

Clinical effect not specified

Source: DDInter

Etanercept

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Fingolimod

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Golimumab

Severe

Database

Clinical effect not specified

Source: DDInter

Infliximab

Severe

Database

Clinical effect not specified

Source: DDInter

Leflunomide

Severe

Database

Clinical effect not specified

Source: DDInter

Measles Virus Vaccine Live Attenuated

Severe

Database

Clinical effect not specified

Source: DDInter

Mumps Virus Strain B Level Jeryl Lynn Live Antigen

Severe

Database

Clinical effect not specified

Source: DDInter

Related guidelines

Preoperative cardiac evaluation for non-cardiac surgery

AHA · Cardiology · 2025

Heart failure in diabetes

RSSDI · Cardiology · 2023

Skin and soft tissue infections

IDSA · Infectious Diseases · 2010

Hypertension in adults

ICMR · Cardiology · 2019

Pulmonary tuberculosis

RNTCP · Infectious Disease · 2023

Ask House about olaratumab

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team