Amiodarone
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Drug reference
Oxygen
Therapeutic Gas · Respiratory Support Agent
Therapeutic GasRespiratory Support Agent
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
2 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 3 →
- AmiodaroneSevereDatabaseDDInter
- BleomycinSevereDatabaseDDInter
Mechanism
Oxygen functions to increase the partial pressure of oxygen in the inspired air, thereby enhancing the oxygen saturation of hemoglobin and increasing oxygen delivery to tissues. This is crucial for patients experiencing respiratory distress, bronchospasm, or laryngospasm, helping to mitigate hypoxemia and support vital organ function during acute medical emergencies.
Indications
Adrenal insufficiency (during hypotensive crisis under stress)Anaphylaxis (as part of first-line treatment for respiratory distress)Asthma (during an attack, especially if unresponsive to bronchodilators or while awaiting transfer to hospital)correction of hypoxiareduction of partial pressure of an inert gas (e.g., in bowel distension, air embolism, decompression sickness)hyperbaric oxygen therapy (e.g., trauma, burns, infections, carbon monoxide poisoning, chronic refractory osteomyelitis)
Dosing
- Adult
- Glucose p. 1102 (for administration by mouth) Glyceryl trinitrate Spray p. 232 Midazolam Oromucosal Solution p. 356 Oxygen Salbutamol Aerosol Inhalation, salbutamol 100 micrograms/metered inhalation p. 267 Adrenal insufficiency Adrenal insufficiency may follow prolonged therapy with corticosteroids and can persist for years after stopping.…
- Max dose
- humidified O2 should be used for prolonged therapy (>1 h)
Contraindications
- neonates with congenital heart disease and left-to-right shunting (supplementation must be regulated carefully due to risk of further reducing pulmonary vascular resistance and increasing pulmonary blood flow)
Side effects
Common
small degree of respiratory depression (in normal subjects)slightly reduced heart rate and cardiac output (with 100% O2)drying and irritation of mucosal surfaces of the airway and eyes (with high flows of dry O2)decreased mucociliary transport and clearance of secretions (with high flows of dry O2)
Serious
- absorption atelectasis and paradoxical worsening of hypoxemia (with high O2 concentrations)
- pulmonary toxicity
- retinopathy of prematurity (in premature infants)
- CNS toxicity (seizures, visual changes) only under hyperbaric conditions
Drug interactions
Bleomycin
Severe
Database
Clinical effect not specified
Source: DDInter
Nitrous Oxide
Moderate
Textbook
Diffusion hypoxia.
Prevent diffusion hypoxia by continuing 100% oxygen inhalation for a few minutes after discontinuing nitrous oxide, instead of immediately switching to air.
Source: KDT 7e · p376
Related guidelines
Ask House about Oxygen
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Sources: Goodman & Gilman 14e, BNF·Verified: 2026-05-13 · House clinical team