Lithium
Severe
Textbook
Prolonged paralysis.
Not explicitly stated
Source: KDT 7e
Drug reference
Pancuronium
Neuromuscular Blocker · Neuromuscular blockade; Anaesthesia
Also known as Pancuronium bromide
Neuromuscular BlockerNeuromuscular blockade; Anaesthesia
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
Mildly prolonged maternal neuromuscular
FDA category + note
Top interactionssee all 12 →
- LithiumSevereTextbookKDT 7e
- AmikacinSevereDatabaseDDInter
- Botulinum Toxin Type ASevereDatabaseDDInter
- Botulinum Toxin Type BSevereDatabaseDDInter
Mechanism
Pancuronium competes with acetylcholine for receptor sites at the neuromuscular junction.
Indications
Enable light anaesthesia with adequate relaxation of the muscles of the abdomen and diaphragmRelax vocal cords to allow passage of a tracheal tubeLong-term mechanical ventilation in intensive care unitsAdjuvant in surgical anesthesia to obtain relaxation of skeletal muscleProlonged operations, especially neurosurgery
Dosing
- Adult
- although duration of action is dose-dependent. Drugs with a shorter or intermediate duration of action, such as atracurium besilate and vecuronium bromide p. 1409, are more widely used than those with a longer duration of action, such as pancuronium bromide.…
Pharmacokinetics
Onset
Slower than suxamethonium chloride
Duration
Long (60
–120 minutes)
Excretion
Renal and hepatic elimination (plasma clearance prolonged by 30-50% in geriatric patients)
Contraindications
- Use with caution in patients with hepatic or renal dysfunction
Side effects
Common
TachycardiaHypertensionRise in blood pressure and tachycardia (with rapid i.v. injection due to vagal blockade and noradrenaline release)
Serious
- Vagolytic action (tachycardia)
- Hypertension
- Increased cardiac output (due to vagolytic activity)
- Less ganglionic blockade at common clinical doses
Pregnancy & lactation
Pregnancy
Mildly prolonged maternal neuromuscular
Drug interactions
Amikacin
Severe
Database
Clinical effect not specified
Source: DDInter
Botulinum Toxin Type A
Severe
Database
Clinical effect not specified
Source: DDInter
Botulinum Toxin Type B
Severe
Database
Clinical effect not specified
Source: DDInter
Colistimethate
Severe
Database
Clinical effect not specified
Source: DDInter
Kanamycin
Severe
Database
Clinical effect not specified
Source: DDInter
Netilmicin
Severe
Database
Clinical effect not specified
Source: DDInter
Paromomycin
Severe
Database
Clinical effect not specified
Source: DDInter
Plazomicin
Severe
Database
Clinical effect not specified
Source: DDInter
Polymyxin B
Severe
Database
Clinical effect not specified
Source: DDInter
Streptomycin
Severe
Database
Clinical effect not specified
Source: DDInter
Tobramycin
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Neuromuscular Blocker drugs
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Textbook-sourced·Sources: KD Tripathi 7e, Goodman & Gilman 14e, BNF·Updated: 2026-05-13